CovidFranceV1, Main, Exploration, bibRecord, 000718

Review of trials currently testing treatment and prevention of COVID-19.

Identifieur interne : 000718 ( Main/Exploration ); précédent : 000717; suivant : 000719

Review of trials currently testing treatment and prevention of COVID-19.

Auteurs : P C Fragkou [Suisse] ; D. Belhadi [France] ; N. Peiffer-Smadja [France] ; C D Moschopoulos [Grèce] ; F-X Lescure [France] ; H. Janocha [Allemagne] ; E. Karofylakis [Grèce] ; Y. Yazdanpanah [France] ; F. Mentré [France] ; C. Skevaki [Allemagne] ; C. Laouénan [France] ; S. Tsiodras [Suisse]

Source :

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases [ 1469-0691 ] ; 2020.

RBID : pubmed:32454187

Descripteurs français

KwdFr :
- Antiviraux (pharmacologie), Antiviraux (usage thérapeutique), Betacoronavirus (effets des médicaments et des substances chimiques), Essais cliniques comme sujet (MeSH), Essais contrôlés randomisés comme sujet (MeSH), Humains (MeSH), Infections à coronavirus (thérapie), Infections à coronavirus (virologie), Pandémies (MeSH), Pneumopathie virale (thérapie), Pneumopathie virale (virologie), Résultat thérapeutique (MeSH), Thérapie cellulaire et tissulaire (méthodes).
MESH :
- effets des médicaments et des substances chimiques : Betacoronavirus.
- méthodes : Thérapie cellulaire et tissulaire.
- pharmacologie : Antiviraux.
- thérapie : Infections à coronavirus, Pneumopathie virale.
- usage thérapeutique : Antiviraux.
- virologie : Infections à coronavirus, Pneumopathie virale.
- Essais cliniques comme sujet, Essais contrôlés randomisés comme sujet, Humains, Pandémies, Résultat thérapeutique.

English descriptors

KwdEn :
- Antiviral Agents (pharmacology), Antiviral Agents (therapeutic use), Betacoronavirus (drug effects), Cell- and Tissue-Based Therapy (methods), Clinical Trials as Topic (MeSH), Coronavirus Infections (therapy), Coronavirus Infections (virology), Humans (MeSH), Pandemics (MeSH), Pneumonia, Viral (therapy), Pneumonia, Viral (virology), Randomized Controlled Trials as Topic (MeSH), Treatment Outcome (MeSH).
MESH :
- chemical , pharmacology : Antiviral Agents.
- chemical , therapeutic use : Antiviral Agents.
- drug effects : Betacoronavirus.
- methods : Cell- and Tissue-Based Therapy.
- therapy : Coronavirus Infections, Pneumonia, Viral.
- virology : Coronavirus Infections, Pneumonia, Viral.
- Clinical Trials as Topic, Humans, Pandemics, Randomized Controlled Trials as Topic, Treatment Outcome.

Abstract

BACKGROUND

As COVID-19 cases continue to rise globally, evidence from large randomized controlled trials is still lacking. Currently, numerous trials testing potential treatment and preventative options are being undertaken all over the world.

OBJECTIVES

We summarized all registered clinical trials examining treatment and prevention options for COVID-19. Additionally, we evaluated the quality of the retrieved studies.

DATA SOURCES

Clinicaltrials.gov, the Chinese Clinical Trial Registry and the European Union Clinical Trials Register were systematically searched.

STUDY ELIGIBILITY CRITERIA

Registered clinical trials examining treatment and/or prevention options for COVID-19 were included. No language, country or study design restrictions were applied. We excluded withdrawn or cancelled studies and trials not reporting therapeutic or preventative strategies for COVID-19.

PARTICIPANTS AND INTERVENTIONS

No restrictions in terms of participants' age and medical background or type of intervention were enforced.

METHODS

The registries were searched using the term 'coronavirus' or 'COVID-19' from their inception until 26 March 2020. Additional manual search of the registries was also performed. Eligible studies were summarized and tabulated. Interventional trials were methodologically analysed, excluding expanded access studies and trials testing traditional Chinese medicine.

RESULTS

In total, 309 trials evaluating therapeutic management options, 23 studies assessing preventive strategies and three studies examining both were retrieved. Finally, 214 studies were methodologically reviewed. Interventional treatment studies were mostly randomized (n = 150/198, 76%) and open label (n = 73/198, 37%) with a median number of planned inclusions of 90 (interquartile range 40-200). Major categories of interventions that are currently being investigated are discussed.

CONCLUSIONS

Numerous clinical trials have been registered since the onset of the COVID-19 pandemic. Summarized data on these trials will assist physicians and researchers to promote patient care and guide future research efforts for COVID-19 pandemic containment.

DOI: 10.1016/j.cmi.2020.05.019
PubMed: 32454187
PubMed Central: PMC7245266

Affiliations:

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<author><name sortKey="Fragkou, P C" sort="Fragkou, P C" uniqKey="Fragkou P" first="P C" last="Fragkou">P C Fragkou</name>
<affiliation wicri:level="1"><nlm:affiliation>4th Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, Attikon University Hospital, Athens, Greece; European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Study Group for Respiratory Viruses (ESGREV), Switzerland. Electronic address: evita.fragou@gmail.com.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>4th Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, Attikon University Hospital, Athens, Greece; European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Study Group for Respiratory Viruses (ESGREV)</wicri:regionArea>
<wicri:noRegion>Greece; European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Study Group for Respiratory Viruses (ESGREV)</wicri:noRegion>
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<author><name sortKey="Belhadi, D" sort="Belhadi, D" uniqKey="Belhadi D" first="D" last="Belhadi">D. Belhadi</name>
<affiliation wicri:level="3"><nlm:affiliation>Université de Paris, IAME, INSERM, F-75018 Paris, France; Département d'Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat - Claude-Bernard, AP-HP, 75018 Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université de Paris, IAME, INSERM, F-75018 Paris, France; Département d'Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat - Claude-Bernard, AP-HP, 75018 Paris</wicri:regionArea>
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<author><name sortKey="Peiffer Smadja, N" sort="Peiffer Smadja, N" uniqKey="Peiffer Smadja N" first="N" last="Peiffer-Smadja">N. Peiffer-Smadja</name>
<affiliation wicri:level="3"><nlm:affiliation>Université de Paris, IAME, INSERM, F-75018 Paris, France; Infectious Diseases Department, Bichat-Claude Bernard Hospital, Assistance-Publique Hôpitaux de Paris, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université de Paris, IAME, INSERM, F-75018 Paris, France; Infectious Diseases Department, Bichat-Claude Bernard Hospital, Assistance-Publique Hôpitaux de Paris, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
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<author><name sortKey="Moschopoulos, C D" sort="Moschopoulos, C D" uniqKey="Moschopoulos C" first="C D" last="Moschopoulos">C D Moschopoulos</name>
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<country xml:lang="fr">Grèce</country>
<wicri:regionArea>4th Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, Attikon University Hospital, Athens</wicri:regionArea>
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<author><name sortKey="Lescure, F X" sort="Lescure, F X" uniqKey="Lescure F" first="F-X" last="Lescure">F-X Lescure</name>
<affiliation wicri:level="3"><nlm:affiliation>Université de Paris, IAME, INSERM, F-75018 Paris, France; Infectious Diseases Department, Bichat-Claude Bernard Hospital, Assistance-Publique Hôpitaux de Paris, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université de Paris, IAME, INSERM, F-75018 Paris, France; Infectious Diseases Department, Bichat-Claude Bernard Hospital, Assistance-Publique Hôpitaux de Paris, Paris</wicri:regionArea>
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<author><name sortKey="Janocha, H" sort="Janocha, H" uniqKey="Janocha H" first="H" last="Janocha">H. Janocha</name>
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<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Laboratory Medicine, Universities of Giessen and Marburg Lung Centre (UGMLC), Philipps University Marburg, German Centre for Lung Research (DZL) Marburg</wicri:regionArea>
<wicri:noRegion>German Centre for Lung Research (DZL) Marburg</wicri:noRegion>
<wicri:noRegion>German Centre for Lung Research (DZL) Marburg</wicri:noRegion>
<wicri:noRegion>German Centre for Lung Research (DZL) Marburg</wicri:noRegion>
</affiliation>
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<author><name sortKey="Karofylakis, E" sort="Karofylakis, E" uniqKey="Karofylakis E" first="E" last="Karofylakis">E. Karofylakis</name>
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<country xml:lang="fr">Grèce</country>
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<author><name sortKey="Yazdanpanah, Y" sort="Yazdanpanah, Y" uniqKey="Yazdanpanah Y" first="Y" last="Yazdanpanah">Y. Yazdanpanah</name>
<affiliation wicri:level="3"><nlm:affiliation>Université de Paris, IAME, INSERM, F-75018 Paris, France; Infectious Diseases Department, Bichat-Claude Bernard Hospital, Assistance-Publique Hôpitaux de Paris, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université de Paris, IAME, INSERM, F-75018 Paris, France; Infectious Diseases Department, Bichat-Claude Bernard Hospital, Assistance-Publique Hôpitaux de Paris, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
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<author><name sortKey="Mentre, F" sort="Mentre, F" uniqKey="Mentre F" first="F" last="Mentré">F. Mentré</name>
<affiliation wicri:level="3"><nlm:affiliation>Université de Paris, IAME, INSERM, F-75018 Paris, France; Département d'Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat - Claude-Bernard, AP-HP, 75018 Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université de Paris, IAME, INSERM, F-75018 Paris, France; Département d'Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat - Claude-Bernard, AP-HP, 75018 Paris</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Skevaki, C" sort="Skevaki, C" uniqKey="Skevaki C" first="C" last="Skevaki">C. Skevaki</name>
<affiliation wicri:level="1"><nlm:affiliation>European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Study Group for Respiratory Viruses (ESGREV), Switzerland; Institute of Laboratory Medicine, Universities of Giessen and Marburg Lung Centre (UGMLC), Philipps University Marburg, German Centre for Lung Research (DZL) Marburg, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Study Group for Respiratory Viruses (ESGREV), Switzerland; Institute of Laboratory Medicine, Universities of Giessen and Marburg Lung Centre (UGMLC), Philipps University Marburg, German Centre for Lung Research (DZL) Marburg</wicri:regionArea>
<wicri:noRegion>German Centre for Lung Research (DZL) Marburg</wicri:noRegion>
<wicri:noRegion>German Centre for Lung Research (DZL) Marburg</wicri:noRegion>
<wicri:noRegion>German Centre for Lung Research (DZL) Marburg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Laouenan, C" sort="Laouenan, C" uniqKey="Laouenan C" first="C" last="Laouénan">C. Laouénan</name>
<affiliation wicri:level="3"><nlm:affiliation>Université de Paris, IAME, INSERM, F-75018 Paris, France; Département d'Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat - Claude-Bernard, AP-HP, 75018 Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université de Paris, IAME, INSERM, F-75018 Paris, France; Département d'Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat - Claude-Bernard, AP-HP, 75018 Paris</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tsiodras, S" sort="Tsiodras, S" uniqKey="Tsiodras S" first="S" last="Tsiodras">S. Tsiodras</name>
<affiliation wicri:level="1"><nlm:affiliation>4th Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, Attikon University Hospital, Athens, Greece; European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Study Group for Respiratory Viruses (ESGREV), Switzerland.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>4th Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, Attikon University Hospital, Athens, Greece; European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Study Group for Respiratory Viruses (ESGREV)</wicri:regionArea>
<wicri:noRegion>Greece; European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Study Group for Respiratory Viruses (ESGREV)</wicri:noRegion>
</affiliation>
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<series><title level="j">Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases</title>
<idno type="eISSN">1469-0691</idno>
<imprint><date when="2020" type="published">2020</date>
</imprint>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antiviral Agents (pharmacology)</term>
<term>Antiviral Agents (therapeutic use)</term>
<term>Betacoronavirus (drug effects)</term>
<term>Cell- and Tissue-Based Therapy (methods)</term>
<term>Clinical Trials as Topic (MeSH)</term>
<term>Coronavirus Infections (therapy)</term>
<term>Coronavirus Infections (virology)</term>
<term>Humans (MeSH)</term>
<term>Pandemics (MeSH)</term>
<term>Pneumonia, Viral (therapy)</term>
<term>Pneumonia, Viral (virology)</term>
<term>Randomized Controlled Trials as Topic (MeSH)</term>
<term>Treatment Outcome (MeSH)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Antiviraux (pharmacologie)</term>
<term>Antiviraux (usage thérapeutique)</term>
<term>Betacoronavirus (effets des médicaments et des substances chimiques)</term>
<term>Essais cliniques comme sujet (MeSH)</term>
<term>Essais contrôlés randomisés comme sujet (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Infections à coronavirus (thérapie)</term>
<term>Infections à coronavirus (virologie)</term>
<term>Pandémies (MeSH)</term>
<term>Pneumopathie virale (thérapie)</term>
<term>Pneumopathie virale (virologie)</term>
<term>Résultat thérapeutique (MeSH)</term>
<term>Thérapie cellulaire et tissulaire (méthodes)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiviral Agents</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Betacoronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Betacoronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Cell- and Tissue-Based Therapy</term>
</keywords>
<keywords scheme="MESH" qualifier="méthodes" xml:lang="fr"><term>Thérapie cellulaire et tissulaire</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antiviraux</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="thérapie" xml:lang="fr"><term>Infections à coronavirus</term>
<term>Pneumopathie virale</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antiviraux</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à coronavirus</term>
<term>Pneumopathie virale</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Clinical Trials as Topic</term>
<term>Humans</term>
<term>Pandemics</term>
<term>Randomized Controlled Trials as Topic</term>
<term>Treatment Outcome</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Essais cliniques comme sujet</term>
<term>Essais contrôlés randomisés comme sujet</term>
<term>Humains</term>
<term>Pandémies</term>
<term>Résultat thérapeutique</term>
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<front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b>
</p>
<p>As COVID-19 cases continue to rise globally, evidence from large randomized controlled trials is still lacking. Currently, numerous trials testing potential treatment and preventative options are being undertaken all over the world.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>OBJECTIVES</b>
</p>
<p>We summarized all registered clinical trials examining treatment and prevention options for COVID-19. Additionally, we evaluated the quality of the retrieved studies.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>DATA SOURCES</b>
</p>
<p>Clinicaltrials.gov, the Chinese Clinical Trial Registry and the European Union Clinical Trials Register were systematically searched.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>STUDY ELIGIBILITY CRITERIA</b>
</p>
<p>Registered clinical trials examining treatment and/or prevention options for COVID-19 were included. No language, country or study design restrictions were applied. We excluded withdrawn or cancelled studies and trials not reporting therapeutic or preventative strategies for COVID-19.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>PARTICIPANTS AND INTERVENTIONS</b>
</p>
<p>No restrictions in terms of participants' age and medical background or type of intervention were enforced.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>METHODS</b>
</p>
<p>The registries were searched using the term 'coronavirus' or 'COVID-19' from their inception until 26 March 2020. Additional manual search of the registries was also performed. Eligible studies were summarized and tabulated. Interventional trials were methodologically analysed, excluding expanded access studies and trials testing traditional Chinese medicine.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>In total, 309 trials evaluating therapeutic management options, 23 studies assessing preventive strategies and three studies examining both were retrieved. Finally, 214 studies were methodologically reviewed. Interventional treatment studies were mostly randomized (n = 150/198, 76%) and open label (n = 73/198, 37%) with a median number of planned inclusions of 90 (interquartile range 40-200). Major categories of interventions that are currently being investigated are discussed.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b>
</p>
<p>Numerous clinical trials have been registered since the onset of the COVID-19 pandemic. Summarized data on these trials will assist physicians and researchers to promote patient care and guide future research efforts for COVID-19 pandemic containment.</p>
</div>
</front>
</TEI>
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<DateCompleted><Year>2020</Year>
<Month>08</Month>
<Day>11</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>09</Month>
<Day>25</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1469-0691</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>26</Volume>
<Issue>8</Issue>
<PubDate><Year>2020</Year>
<Month>Aug</Month>
</PubDate>
</JournalIssue>
<Title>Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases</Title>
<ISOAbbreviation>Clin. Microbiol. Infect.</ISOAbbreviation>
</Journal>
<ArticleTitle>Review of trials currently testing treatment and prevention of COVID-19.</ArticleTitle>
<Pagination><MedlinePgn>988-998</MedlinePgn>
</Pagination>
<ELocationID EIdType="pii" ValidYN="Y">S1198-743X(20)30296-2</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.cmi.2020.05.019</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">As COVID-19 cases continue to rise globally, evidence from large randomized controlled trials is still lacking. Currently, numerous trials testing potential treatment and preventative options are being undertaken all over the world.</AbstractText>
<AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">We summarized all registered clinical trials examining treatment and prevention options for COVID-19. Additionally, we evaluated the quality of the retrieved studies.</AbstractText>
<AbstractText Label="DATA SOURCES" NlmCategory="METHODS">Clinicaltrials.gov, the Chinese Clinical Trial Registry and the European Union Clinical Trials Register were systematically searched.</AbstractText>
<AbstractText Label="STUDY ELIGIBILITY CRITERIA" NlmCategory="METHODS">Registered clinical trials examining treatment and/or prevention options for COVID-19 were included. No language, country or study design restrictions were applied. We excluded withdrawn or cancelled studies and trials not reporting therapeutic or preventative strategies for COVID-19.</AbstractText>
<AbstractText Label="PARTICIPANTS AND INTERVENTIONS" NlmCategory="METHODS">No restrictions in terms of participants' age and medical background or type of intervention were enforced.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">The registries were searched using the term 'coronavirus' or 'COVID-19' from their inception until 26 March 2020. Additional manual search of the registries was also performed. Eligible studies were summarized and tabulated. Interventional trials were methodologically analysed, excluding expanded access studies and trials testing traditional Chinese medicine.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">In total, 309 trials evaluating therapeutic management options, 23 studies assessing preventive strategies and three studies examining both were retrieved. Finally, 214 studies were methodologically reviewed. Interventional treatment studies were mostly randomized (n = 150/198, 76%) and open label (n = 73/198, 37%) with a median number of planned inclusions of 90 (interquartile range 40-200). Major categories of interventions that are currently being investigated are discussed.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Numerous clinical trials have been registered since the onset of the COVID-19 pandemic. Summarized data on these trials will assist physicians and researchers to promote patient care and guide future research efforts for COVID-19 pandemic containment.</AbstractText>
<CopyrightInformation>Copyright © 2020 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Fragkou</LastName>
<ForeName>P C</ForeName>
<Initials>PC</Initials>
<AffiliationInfo><Affiliation>4th Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, Attikon University Hospital, Athens, Greece; European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Study Group for Respiratory Viruses (ESGREV), Switzerland. Electronic address: evita.fragou@gmail.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Belhadi</LastName>
<ForeName>D</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Université de Paris, IAME, INSERM, F-75018 Paris, France; Département d'Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat - Claude-Bernard, AP-HP, 75018 Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Peiffer-Smadja</LastName>
<ForeName>N</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>Université de Paris, IAME, INSERM, F-75018 Paris, France; Infectious Diseases Department, Bichat-Claude Bernard Hospital, Assistance-Publique Hôpitaux de Paris, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Moschopoulos</LastName>
<ForeName>C D</ForeName>
<Initials>CD</Initials>
<AffiliationInfo><Affiliation>4th Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, Attikon University Hospital, Athens, Greece.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lescure</LastName>
<ForeName>F-X</ForeName>
<Initials>FX</Initials>
<AffiliationInfo><Affiliation>Université de Paris, IAME, INSERM, F-75018 Paris, France; Infectious Diseases Department, Bichat-Claude Bernard Hospital, Assistance-Publique Hôpitaux de Paris, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Janocha</LastName>
<ForeName>H</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Institute of Laboratory Medicine, Universities of Giessen and Marburg Lung Centre (UGMLC), Philipps University Marburg, German Centre for Lung Research (DZL) Marburg, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Karofylakis</LastName>
<ForeName>E</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>4th Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, Attikon University Hospital, Athens, Greece.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yazdanpanah</LastName>
<ForeName>Y</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Université de Paris, IAME, INSERM, F-75018 Paris, France; Infectious Diseases Department, Bichat-Claude Bernard Hospital, Assistance-Publique Hôpitaux de Paris, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mentré</LastName>
<ForeName>F</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Université de Paris, IAME, INSERM, F-75018 Paris, France; Département d'Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat - Claude-Bernard, AP-HP, 75018 Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Skevaki</LastName>
<ForeName>C</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Study Group for Respiratory Viruses (ESGREV), Switzerland; Institute of Laboratory Medicine, Universities of Giessen and Marburg Lung Centre (UGMLC), Philipps University Marburg, German Centre for Lung Research (DZL) Marburg, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Laouénan</LastName>
<ForeName>C</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Université de Paris, IAME, INSERM, F-75018 Paris, France; Département d'Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat - Claude-Bernard, AP-HP, 75018 Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tsiodras</LastName>
<ForeName>S</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>4th Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, Attikon University Hospital, Athens, Greece; European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Study Group for Respiratory Viruses (ESGREV), Switzerland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><CollectiveName>ESCMID Study Group for Respiratory Viruses</CollectiveName>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D016454">Review</PublicationType>
<PublicationType UI="D000078182">Systematic Review</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2020</Year>
<Month>05</Month>
<Day>23</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Clin Microbiol Infect</MedlineTA>
<NlmUniqueID>9516420</NlmUniqueID>
<ISSNLinking>1198-743X</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance>
</Chemical>
</ChemicalList>
<SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName>
<SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName>
</SupplMeshList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000998" MajorTopicYN="N">Antiviral Agents</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
<QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="N">Betacoronavirus</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D064987" MajorTopicYN="N">Cell- and Tissue-Based Therapy</DescriptorName>
<QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002986" MajorTopicYN="N">Clinical Trials as Topic</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName>
<QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName>
<QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016032" MajorTopicYN="N">Randomized Controlled Trials as Topic</DescriptorName>
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<MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName>
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<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Anti-inflammatory</Keyword>
<Keyword MajorTopicYN="N">Antivirals</Keyword>
<Keyword MajorTopicYN="N">COVID-19</Keyword>
<Keyword MajorTopicYN="N">Clinical trials</Keyword>
<Keyword MajorTopicYN="N">Immunomodulators</Keyword>
<Keyword MajorTopicYN="N">Novel coronavirus</Keyword>
<Keyword MajorTopicYN="N">Pneumonia</Keyword>
<Keyword MajorTopicYN="N">Prevention</Keyword>
<Keyword MajorTopicYN="N">SARS-CoV-2</Keyword>
<Keyword MajorTopicYN="N">Treatment</Keyword>
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<Month>04</Month>
<Day>14</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2020</Year>
<Month>05</Month>
<Day>15</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2020</Year>
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<name sortKey="Peiffer Smadja, N" sort="Peiffer Smadja, N" uniqKey="Peiffer Smadja N" first="N" last="Peiffer-Smadja">N. Peiffer-Smadja</name>
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	Serveur d'exploration sur la COVID en France
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Review of trials currently testing treatment and prevention of COVID-19.

Review of trials currently testing treatment and prevention of COVID-19.

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